PT Journal
AU Ramakrishnan, S
   Jebastin, T
   Raj, S
   Ramathilaga, A
   Selvaraj, R
   A., BNA
   Hatamleh, AA
   Ahamed, A
TI Anti-diabetic effect of rice extract constituents through the molecular inhibition of α-amylase and α-glucosidase activity
SO Plant, Soil and Environment
PY 2024
BP 683
EP 694
VL 70
IS 11
DI 10.17221/150/2024-PSE
DE Type2 Diabetes mellitus; hyperglycemic; carbohydrate hydrolysing enzymes; antioxidant activity; molecular interaction
AB Carbohydrate digestive enzymes like α-amylase and α-glucosidase can be used to treat and manage diabetes. By inhibiting these enzymes, carbohydrate digestion slowed down, lowering the level of glucose entry into the bloodstream and preventing postprandial hyperglycemia. However, the effectiveness of current antidiabetic agents is limited due to their adverse effects. Therefore, the current study explored natural inhibitors from the methanol extract of rice to combat this issue. Through an integrated approach, four different rice cultivars were analysed and found that red rice methanol extract compounds stigmasterol and 1,2-benzenedicarboxylic acid interacted with α-amylase and α-glucosidase. Additionally, further research on stigmasterol directs the structure-activity relationship studies that aid in managing diabetic conditions.
ER