RT Journal Article
SR Electronic
A1 Ramakrishnan, Subhashini
A1 Jebastin, Thomas
A1 Raj, Sumathy
A1 Ramathilaga, Ariyamuthu
A1 Selvaraj, Rithik
A1 A., Najat A. Bukhari
A1 Hatamleh, Ashraf Atef
A1 Ahamed, Anis
T1 Anti-diabetic effect of rice extract constituents through the molecular inhibition of α-amylase and α-glucosidase activity
JF Plant, Soil and Environment
YR 2024
VO 70
IS 11
SP 683
OP 694
DO 10.17221/150/2024-PSE
UL https://pse.agriculturejournals.cz/artkey/pse-202411-0001.php
AB Carbohydrate digestive enzymes like α-amylase and α-glucosidase can be used to treat and manage diabetes. By inhibiting these enzymes, carbohydrate digestion slowed down, lowering the level of glucose entry into the bloodstream and preventing postprandial hyperglycemia. However, the effectiveness of current antidiabetic agents is limited due to their adverse effects. Therefore, the current study explored natural inhibitors from the methanol extract of rice to combat this issue. Through an integrated approach, four different rice cultivars were analysed and found that red rice methanol extract compounds stigmasterol and 1,2-benzenedicarboxylic acid interacted with α-amylase and α-glucosidase. Additionally, further research on stigmasterol directs the structure-activity relationship studies that aid in managing diabetic conditions.