Plant Soil Environ., 2024, 70(11):683-694 | DOI: 10.17221/150/2024-PSE
Anti-diabetic effect of rice extract constituents through the molecular inhibition of α-amylase and α-glucosidase activityOriginal Paper
- 1 Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India
- 2 Computer Aided Drug Designing Lab, Department of Bioinformatics, Bishop Heber College (Autonomous), Tamil Nadu, India
- 3 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
Carbohydrate digestive enzymes like α-amylase and α-glucosidase can be used to treat and manage diabetes. By inhibiting these enzymes, carbohydrate digestion slowed down, lowering the level of glucose entry into the bloodstream and preventing postprandial hyperglycemia. However, the effectiveness of current antidiabetic agents is limited due to their adverse effects. Therefore, the current study explored natural inhibitors from the methanol extract of rice to combat this issue. Through an integrated approach, four different rice cultivars were analysed and found that red rice methanol extract compounds stigmasterol and 1,2-benzenedicarboxylic acid interacted with α-amylase and α-glucosidase. Additionally, further research on stigmasterol directs the structure-activity relationship studies that aid in managing diabetic conditions.
Keywords: Type2 Diabetes mellitus; hyperglycemic; carbohydrate hydrolysing enzymes; antioxidant activity; molecular interaction
Received: April 7, 2024; Revised: July 14, 2024; Accepted: July 16, 2024; Prepublished online: September 30, 2024; Published: October 17, 2024 Show citation
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